Community Research and Development Information Service - CORDIS


Final Report - PRISM (Phospholipid and Glycolipid Recognition, Interactions and Structures by Magnetic Resonance)

Project ID: 37740


This is the final report for PRISM which was a specific targeted research project intended to use cutting-edge Nuclear magnetic resonance (NMR) techniques to develop a sensitive, rapid and integrated approach to understanding the mechanisms of lipid binding proteins. The project accelerated the efforts to characterise a range of peripheral membrane proteins, thus providing new insight into an important class of proteins which play a key role in regulating complex cellular pathways. Their final report includes an image of the project logo and emphasises that PRISM has yielded multistep binding mechanisms for biomolecular systems that adapt and respond to their molecular environments. This has long-term potential for applications such as drugs that act specifically on protein-lipid interfaces, and biochemicals agents which regulate the assembly and subcellular localisation of proteins in vivo.

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