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FP6

Final Report - SHIVA (Selection and development of Microbicides for mucosal use to prevent sexual HIV transmission / acquisition)

Project ID: 503162
Funded under: FP6-LIFESCIHEALTH

Abstract

This is the final report for the SHIVA project which was part of a novel strategy to fight the transmission of HIV by means of microbicides. Designed for mucosal use, they would provide a convenient and readily available method of self-protection against HIV. Some members of a new class of Non-nucleoside reverse transcriptase inhibitors (NNRTIs), the the Dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), proved to be capable of irreversibly knocking out the HIV-1 replication. Their final report details the trials and successes of the project. Unfortunately, the first liposomal formulation of the MC-1220 developed in the SHIVA project, provided a 55 % protection at a concentration of 0.5 %. Surprisingly, when the concentration was increased from 0.5 % to 1.5 % the protection did not increase. This was probably due to a high affinity of the drug for liposomes and its low solubility in the aqueous environments.

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