Community Research and Development Information Service - CORDIS

FP6

Final Report - DC-VACC (Dendritic cells as natural adjuvants for novel vaccine technologies)

Project ID: 503037
Funded under: FP6-LIFESCIHEALTH

Abstract

This is the final report of the DC-VACC project whose aim was to develop novel vaccine technologies and to use DC as natural adjuvants with specificity and minimum side effects. This report describes the work completed, including the generation of improved reagents and protocols for antigen delivery and targeting, which improve antigen processing and presentation by DC and can be used for vaccine and therapeutic technology. It also defines optimal reagents and protocols for maturation and activation of mouse and human DC in vitro for use in vaccination and / or therapeutic intervention. Optimisation of protocols has been compared across both species, essential for use in pre-clinical models and clinical trials in future NoEs and / or Ips.

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