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FP6

Final Report - STROMA (Selective targeting of angiogenesis and of tumor stroma)

Project ID: 503233
Funded under: FP6-LIFESCIHEALTH

Abstract

This is the final report of the STROMA project aimed at the development of selective and efficacious anti-cancer therapeutics, by means of the targeted delivery of potent bioactive moieties to the tumour-associated antigens, located in the neo-vasculature and / or the tumour stroma, thus sparing normal tissues. Fluorescence images of whole tumour sections, charts, graphs and other images are included in the report which also lists published results. The project concludes that throughout the STROMA project several molecular candidates targeting the tumour vasculature and / or the stroma have been characterised in preclinical models. Their anti-tumour activity has been extensively studied in complex tumour systems alone and in combination with conventional chemotherapy, providing basis for clinical development.

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