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FP6

Final Report - MOLEDA (Molecular optimization of laser/electrotransfer DNA administration into muscle and skin for gene therapy)

Project ID: 512034
Funded under: FP6-LIFESCIHEALTH

Abstract

This is the final report for the MOLEDA project which aimed to determine the optimal conditions for precise and selective plasmid transfer into skeletal muscle and skin, in the frame of a head-to-head comparison between the two most promising in vivo plasmid DNA delivery technologies at present, and to introduce molecular strategies to improve these technologies. The report notes that the project has made great progress by constructing a new generation of high efficiency plasmids devoid of antibiotic resistance genes and their corresponding genetically modified bacterial host.

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