Community Research and Development Information Service - CORDIS

FP7

Final Report - IBDASE (Mucosal protease and their inhibitors in inflammatory bowel disease: from etiopathogenetic insight to innovative therapy)

Project ID: 200931
Funded under: FP7-HEALTH

Abstract

This is the final publishable summary report for the IBDASE project which received funding under the European Commission's Seventh Framework Programme (FP7). IBDASE addresses the etiology and pathogenesis of Inflammatory bowel disease (IBD), a multifactorial disease whose onset and course is influenced by environmental factors in a background of complex genetic susceptibility. The project envisages a multidisciplinary plan for innovative diagnosis and therapy focused on mucosal proteases and their inhibitors (P / PIs).

In view of P / PIs as novel therapeutic targets, IBDASE evaluates their role in IBD through the combination of in vitro, in vivo and ex vivo methodologies from the diverse disciplines, such as human genetics, genetic epidemiology, biochemistry, molecular biology and immunology. The consortium identifies P / PIs that are genetically and / or functionally linked to IBD and reveals pathogenetic pathways. On the basis of these results, therapeutic approaches promoting or inhibiting mucosal P / PIs are proposed.

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Related information

Record Number: 14192 / Last updated on: 2012-07-27
Category: PROJ