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FP7

Final Report - PHENOXIGEN (A systems approach linking genotype and environment to phenotype: oxidative stress response mechanisms in fission yeast)

Project ID: 223539
Funded under: FP7-HEALTH

Abstract

This is the final publishable summary report for the PHENOXIGEN project which received funding under the European Commission's Seventh Framework Programme (FP7). PHENOXIGEN investigates the mechanisms that regulate the oxidative stress response by associating genetic factors to phenotype when the cell is challenged by oxidative stress. The project exploits different strains of fission yeast using a range of genome-wide analyses to interrogate the stress response and its regulation at different levels and under diverse genetic backgrounds. A large and coordinated body of heterogeneous quantitative data is being generated and integrated with published information. Using these data, not only the cellular stress response is described at a much more comprehensive and detailed level than before, but also fundamental biological questions are addressed, such as how natural genetic variability affects a cell's ability to cope with stress, contributing to a systems-level understanding of the oxidative stress response.

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Related information

Record Number: 14385 / Last updated on: 2011-04-14
Category: PROJ
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