Final Report - BETAIMAGE (Use of innovative strategies for beta-cell imaging in diabetes mellitus)
Project ID: 222980Funded under: FP7-HEALTH
This is the final report for the BETAIMAGE project which was funded under the Seventh Framework Package (FP7). The project aimed to develop new approaches for in vitro and in vivo life beta-cell imaging. The report shows that the project researchers have identified several potential new targets, including beta cell specific splice variants of non-beta cell specific targets. Specific ligands for these targets have been developed and for others, development is continued in subsequent projects. The report then goes on to cover how the lead compound (serving as reference) and several analogues have been optimised and labelled with a range of suitable radionuclides for SPECT and PET imaging. Successful in vivo determination of the pancreatic beta cell mass with the lead compound has been achieved and the acquisition and reconstruction protocols have been optimised in rodent models. The report covers dissemination methods and notes that training courses and individual training have been performed, including courses on small animal imaging, labelling techniques, and beta cell transplantation. In addition, several individual trainings have been performed in several places addressing specific needs of BETAIMAGE partners.
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Record Number: 16453 / Last updated on: 2013-09-01