Community Research and Development Information Service - CORDIS

FP7

Final Report - PLASTICISE (Promotion of plasticity as a treatment for neurodegenerative conditions)

Project ID: 223524
Funded under: FP7-HEALTH

Abstract

This is the final report for the PLASTICISE project which was funded under the Seventh Framework Package (FP7). The overall concept behind the PLASTICISE project is that restoration of the function in neurodegenerative conditions can be achieved through plasticity (the formation of new circuits in the nervous system to bypass lesions). Promoting increased plasticity in selected parts of the adult nervous system back to the level seen in children is a powerful method of enhancing recovery of function in animal models of neurological disease. Plasticity-promoting treatments could therefore be beneficial in a wide range of conditions that damage the CNS. As outlined in the report, the project developed new treatment concepts to promote plasticity and methods to measure and visualise their effects, focussing on Alzheimer's disease/tauopathy, stroke and the visual system. In parallel the project has developed new clinical tools that will be needed for clinical trials of plasticity treatments. Clinical investigations and trials were performed, concentrating patients with stroke (the chronic recovery phase, not acute neuroprotection) and Alzheimer's disease.

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