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Final Report - AMYGDALA IMAGING (Functional in vivo two-photon imaging of fear memory traces in identified neuronal networks of the amygdala)

Project ID: 201148
Funded under: FP7-PEOPLE


This is the final report of the AMYGDALA IMAGING project, which is funded under the European Commission (EC) Seventh Framework Programme (FP7). Human anxiety disorders such as phobias and post-traumatic stress disorders are widespread, debilitating conditions. To develop rational therapeutic approaches for them, a detailed understanding of the underlying brain areas and neuronal circuits is required. The aim of this project was to characterise how fear learning is accomplished by identified neurons interacting in local circuits.

The results have considerably advanced our understanding of the brain areas and circuit mechanisms involved in associative fear learning, and established a novel methodology for functional investigation of deep-brain areas like the amygdala. This research has implications for the development of therapeutic approaches to several human conditions, including anxiety disorders, Alzheimer’s disease and tobacco abuse.

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