Community Research and Development Information Service - CORDIS


Final Report - MICE SPINAL CORD CM (Neuronal circuitry and plasticity of the spinal cord using in-vivo electrophysiology in transgenic mice)

Project ID: 236370
Funded under: FP7-PEOPLE


This is the periodic report of the MICE SPINAL CORD CM project, funded under the European Commission's Seventh Framework Programme (FP7). This project hopes to better understand development in transgenic mice in an effort to explain normal spinal function and its dysfunction in disease. This will allow previous techniques used to be adapted for mice. The researchers aim to develop techniques for previously used intracellular recordings of spinal neurones for adult mice in vivo. They will describe the intrinsic properties of mouse motor neurones, compare them with those of cats and rats, and investigate variations in transgenic strains.

A European laboratory has been established capable of conducting such experiments in an adult mouse spinal cord in vivo. In future, the in-vivo mode will be used to study transgenic mice with specific manipulations affecting the development of spinal neuronal circuitry and those with genetic mutations similar to those underlying neurological disorders in humans.

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