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This paper describes the development of the precise determination of certain metals in biological fluids, with particular reference to man, using the isotope dilution mass spectrometry technique. The metals in question include some which are toxic (Cd, Li and Pb) and others which are "essential" (such as Ca, Mg). The range of concentration in which the metals are present is of the order of ppb. The need for a very accurate determination technique has arisen from the growing interest paid by international health organisations and environmental organisations to the problem of environmental pollution, the results of which are sometimes harmful to the exposed populations. In the analytical panorama of inorganic measurements at trace levels, IDMS is already considered to be a method with "reference" characteristics. Considering, however, the instrumental complexity and the cost and time involved as compared to other methods, improvements of these phases are possible and to be hoped for.

Additional information

Authors: RODARI E, JRC Ispra Estab. (IT);TRINCHERINI P R, JRC Ispra Estab. (IT)
Bibliographic Reference: Paper presented: 20 Congresso Nazionale della Societa Italiano di Biochimica Clinica, Roma (IT), Oct. 25-28, 1988
Availability: Available from (1) as Paper IT 34257 ORA
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