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This report discusses the use of definitive and reference methods for the determination of selenium in biological materials. The emphasis is on analysis of reference materials, interlaboratory precision, analytical bias and choice of reference method. Sixteen laboratories have been involved in certification analysis of selenium. The precision that can be achieved by three different methods - Fluorimetry, Hydride Formation Atomic Absorption Spectrometry (HAAS) and Instrumental Neutron Activation Analysis (INAA) - is summarised. In the range of 25-300 microg/kg, Fluorimetry is a reference method, but should be checked by appropriate matrix-matching reference materials. In the range 0.3 to 10 mg/kg, INAA is the reference method, but should be carefully calibrated with pure stoichiometric standards. All three methods are capable of producing unbiased results for selenium in a range of biological materials, provided the laboratory has sufficient experience.

Additional information

Authors: HEYDORN K, RisÝ National Laboratory, Roskilde (DK);GRIEPINK B, CEC, Bruxelles (BE)
Bibliographic Reference: Paper presented: Reference methods for the determination of selenium in biological materials, Andana (TR), April 5-7, 1989
Availability: Available from (1) as Paper EN 34667 ORA
Record Number: 198910558 / Last updated on: 1994-12-01
Original language: en
Available languages: en
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