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  • An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles - Part VII : Lung clearance of inhaled cobalt oxide particles in Sprague-Dawley rats

Abstract

This study is one of a series in which an inhalation facility was developed and the first inhalation experiments were begun with rats. The study compared the biological behaviour of different oxide particles in rat lungs after inhalation and after instillation, with the same types of materials and animals. The aim was to establish the validity of a connection between these two types of in vivo experiments and new in vitro experiments using rat and bovine alveolar macrophages and again the same types of materials. The different materials used so far were aluminium oxide (doped with indium oxide), cerium oxide (doped with europium oxide) and uranium/ plutonium mixed oxide. These studies have been published previously and are compared with the cobalt studies presented here.

Additional information

Authors: DROSSELMEYER E, JRC, Karlsruhe Estab. (DE);MÜLLER H L, JRC, Karlsruhe Estab. (DE);PICKERING S, Biomedical and Environmental Research Institute, Albuquerque (US)
Bibliographic Reference: Article: J. Aerosol Sci., Vol. 20 (1989), No. 2, pp. 257-260
Record Number: 198910824 / Last updated on: 1994-12-01
Category: PUBLICATION
Original language: en
Available languages: en