Late effects after incorporation of the short-lived alpha-emitter 224Ra - Part II : Follow-up studies of 224Ra-treated patients
Severe late effects in humans following intravenous injections of an aqueous mixture containing Radium-224 (Peteosthor) have repeatedly been reported since 1956. These patients, now followed by Spiess and Mays (Study I) received alpha-doses to the skeleton ranging from less than 1 Gy in the adults up to more than 50 Gy in the juveniles. As of 1988, 56 cases of bone sarcoma (mostly osteosarcomas) out of 900 patients were reported compared to only 0.3 cases expected naturally. Study II comprises 1473 ankylosing spondylitis patients injected with much lower doses of Radium-224. Until now, three cases of malignant tumours in the skeleton have been observed compared to an expected number of 0.4 - 0.7 based on general population statistics. Only one bone tumour, a plasmocytoma, has been observed in the control group. Diseases of haematopoietic tissue among living and dead patients included bone marrow failure (10 in the exposure group vs. 7 in the control group) and leukaemias (7 cases vs. 4).
Bibliographic Reference: Paper presented: Seminar of the Argonne National Laboratory, Argonne, Illinois (US), Oct. 6, 1988
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Record Number: 198910864 / Last updated on: 1994-12-01
Original language: en
Available languages: en