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The metabolism of methylated arsenic compounds present in the environment and human foodstuffs has been studied in mice, hamsters, rats, rabbits and human subjects. Arsenobetaine (As-B), the most common arsenic compound in fish and crustacea, is rapidly absorbed and excreted unchanged in the urine. Arsenocholine (As-C), which occurs in certain shrimp species, is rapidly oxidized in the liver to arsenobetaine. Dimethtylarsenic acid (DMA), the major metabolite of inorganic arsenic, a commonly used pesticide and a naturally occurring arsenic compound in certain seaweed, is partly transformed to trimethylarsineoxide (TMAO). Comprehensive metabolic schemes are reported.

Additional information

Authors: MARAFANTE E, JRC, 2120 Ispra (IT);VAHTER M, Institute of Environmental Medicine, Karolinska Institutet, Box 60208, 104 01 Stockholm (SE)
Bibliographic Reference: Paper presented: 7th International Conference on Heavy Metals in the Environment, Genève (CH), Sept. 12-15, 1989
Availability: Available from (1) as Paper EN 34961 ORA
Record Number: 198910908 / Last updated on: 1994-12-01
Original language: en
Available languages: en