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Fluorine concentrations in bone biopsy samples taken from the iliac crest of subjects, divided into four groups depending on the length of dialysis treatment, aluminium levels in blood and bone pathology in terms of osteoporosis, were determined by two instrumental methods. These were proton induced gamma ray emission (PIGE) making use of the resonance reaction of 19F(p,alpha-gamma)16O at 872 keV and cyclic neutron activation analysis (CNAA) using the 19F(n,gamma)20F reaction in a reactor irradiation facility. Rutherford backscattering was used to calculate the volume, and hence mass, of the sample excited in PIGE by determining the major element composition of the samples, in order to express results in terms of concentration. From this preliminary investigation a relationship is suggested between fluorine concentrations in bone and aluminium levels in the system.

Additional information

Authors: SPYROU N M, University of Surrey, Guildford, Surrey GU2 5XH (GB);ALTAF W J, University of Surrey, Guildford, Surrey GU2 5XH (GB);GILL B S, University of Surrey, Guildford, Surrey GU2 5XH (GB);JEYNES C, University of Surrey, Guildford, Surrey GU2 5XH (GB);NICOLAOU G, Radiochemistry Division, JRC Ispra (IT);PIETRA R, Radiochemistry Division, JRC Ispra (IT);SABBIONI E, Radiochemistry Division, JRC Ispra (IT);SURIAN M, Dialysis Service, Maggiore Hospital, Lodi (MI), (IT)
Bibliographic Reference: Paper presented: International Conference "Nuclear Analytical Methods in the Life Sciences", Gaithersburg, Maryland (US)
Availability: Available from (1) as Paper EN 34960 ORA
Record Number: 198910910 / Last updated on: 1994-12-01
Original language: en
Available languages: en