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  • Behaviour of spherical and irregular (U,Pu)O(2) particles after inhalation or intratracheal instillation in rat lung and during in vitro culture with bovine alveolar macrophages


Spherical and irregularly shaped mixed (U,Pu) oxide particles were administered to rats by inhalation and by intratracheal instillation. The lung retention of the particles was independent of particle shape and of the route of adminstration. Only a small percentage of the administered radioactivity was found in other organs. Detailed electron microscopic studies showed particles within membrane-enclosed vacuoles as well as lying free in the cytoplasm.

Additional information

Authors: MÜLLER H L, Kernforschungszentrum Karlsruhe, Postfach 3640, D-7500 Karlsruhe 1 (DE);DROSSELMEYER E, JRC Karlsruhe, Postfach 2340, D-7500, Karlsruhe 1 (DE);HOTZ G, JRC Karlsruhe, Postfach 2340, D-7500, Karlsruhe 1 (DE);SEIDEL A, JRC Karlsruhe, Postfach 2340, D-7500, Karlsruhe 1 (DE);THIELE H, ;PICKERING S,
Bibliographic Reference: Article: Int.J.Radiat. Biol., Vol. 55 (1989), No. 5, pp. 829-841
Record Number: 198911003 / Last updated on: 1994-12-01
Original language: en
Available languages: en