Epidemiological investigations in ankylosing spondylitis patients treated with Radium - 224
This study concerns 1473 ankylosing spondylitis patients treated with the short-lived alpha-emitter Radium 224. In addition there exists a control group of 1336 patients not treated with radioactive drugs or X-rays, in order to provide comparative information on causes of death and lesions possibly related to the basic disease or to chemotherapy. Three cases of tumours in the skeleton have been recorded, when the expected number is 0.4-0.7 cases; within the control group only one case has been observed. Diseases of haematopoietic tissue amongst living and dead patients of both groups are also analysed. In the exposure group three of the leukaemias were of the chronic myeloid type and there was only one of the acute lymphoblastic type, whereas none of chronic myeloid but three of lymphoblastic leukaemias were observed in the control group. This apparent difference is somewhat parallel to the observation that two of the three skeletal tumours are bone marrow tumours, whereas much less had been related to the bone marrow in the higher dose study of SPIESS and MAYS.
Bibliographic Reference: Paper presented: International Conference "Ionising Radiation and Cancer Epidemiology", Birmingham (GB), July 12-13, 1989
Availability: Text not available
Record Number: 198911145 / Last updated on: 1994-12-01
Original language: en
Available languages: en