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The transformation of mammalian cells in vitro provides quantitative and qualitative information on the processes by which physical and chemical agents induce malignancy. Recently, there has been considerable progress on the development of new cell transformation systems and the role of oncogenes in cell transformation. This International Workshop held during April 1989 in Dublin provided a forum for critical review of current research results. It includes work which focuses on the potential of emerging human cell transformation systems and their relevance to radiation carcinogenesis, and on the role and interplay of oncogenes, retroviruses and radiation in cell transformation. Particular emphasis is placed on the influence of such variables as radiation quality, dose and dose rate, promoters and suppressors and cell types on in vitro cell transformation. Also considered are the implications of the results from cell transformation studies for radiation-induced cancer in man and for radiological protection.

Additional information

Authors: CHADWICK K H, CEC, Bruxelles (BE);SEYMOUR C, Saint Luke's Hospital, Dublin (IE);BARNHART B (EDITORS), US DOE, Washington (United States)
Bibliographic Reference: EUR 12248 EN (1989) 414 pp.
Availability: Available from IOP Publishing Ltd, Techno House, Redcliffe Way, Bristol BS1 6NX (GB)
ISBN: ISBN 0-85274-084-0
Record Number: 198911213 / Last updated on: 1994-12-01
Original language: en
Available languages: en
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