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  • Inductively-coupled plasma atomic emission spectrometry and neutron activation analysis for the determination of element reference values in human lung tissue


The main objective of the research is to establish accurate and reliable reference values of trace elements for their subsequent use in toxological studies. There is a need to narrow the range of levels reported in the literature and to minimise the analytical sources of errors. The work includes a study of some factors affecting the determination of trace elements in human lungs together with hilar lymph nodes. Radiotraces were administered to rats and the radioisotopically-labelled lung tissues were used to check the losses during different analytical steps, such as freeze-drying and ashing procedures. Techniques used included NAA and ICP-AES. In particular, methods for the radiochemical separation of the induced radio isotopes in neutron activated samples have been developed, in order to reach maximum sensitivity. Reference values for trace elements in the lungs of Italian subjects are also given. More extensive investigations are now in progress.

Additional information

Authors: SABBIONI E, JRC Ispra, 21020 Ispra (VA) (IT);NICOLAOU G R, JRC Ispra, 21020 Ispra (VA) (IT);PIETRA R, JRC Ispra, 21020 Ispra (VA) (IT);BECCALONI E, Istituto Superiore di Sanità, Roma (IT);CONI E, Istituto Superiore di Sanità, Roma (IT);ALIMONTI A, Istituto Superiore di Sanità, Roma (IT);CAROLI S, Istituto Superiore di Sanità, Roma (IT)
Bibliographic Reference: Paper presented: International Conference "Nuclear Analytical Methods in the Life Sciences", Gaithersburg, Maryland (US), April 17-21, 1989
Availability: Available from (1) as Paper EN 34998 ORA
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