DISTRIBUTION STUDIES IN MICE OF 224-RA IN COLLOIDAL (PETEOSTHOR) AND IONIC PREPARATIONS AS USED IN HUMAN THERAPY
It is important to determine the relative radiation doses in those tissues in which biological effects have been observed or suspected in humans (Sp78; Sp79). The animal experiments described here were performed in order to obtain data which could provide some indications for the dosimetry of short-lived 224-Ra in man. The percentage of total injected 224-Ra retained after either pure 224-Ra or peteosthor application was highest in the skeleton (42-48%). A minor amount was found in the eyes (0.6-0.7%), and even less in kidneys, spleen and liver (Fig.1). Retention of injected platinum (as percentage of total injected amount) was highest in the liver (about 23%). Only traces of platinum were present in the eyes (Fig. 2). No platinum could be identified in the skeleton but, as shown above, it is less than 10%.
Bibliographic Reference: HEALTH PHYSICS, VOL. 44 (1983), SUPPLEMENT NO. 1, PP. 580-583
Record Number: 1989122014400 / Last updated on: 1987-01-01
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