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Abstract

Three dogs were given cryopreserved fetal liver grafts from histocompatible siblings after total body irradiation. Sustained engraftment was achieved in all recipients with low numbers of liver cells and myelomonocytic progenitor cells administered. Recovery of granulocytes and platelets in peripheral blood occurred rapidly. Pre-irradiation values were reached by day 19 for granulocytes and by day 26 for platelets. Lymphocyte recovery was slow, however. In two dogs skin alterations possibly related to graft-versus-host disease were detected macroscopically. Cryopreserved liver cells from 52 day dog fetuses can be used to efficiently restore hemopoiesis in histocompatible siblings.

Additional information

Authors: PRUEMMER O, DEPARTMENT OF CLINICAL PHYSIOLOGY AND OCCUPATIONAL MEDICINE, UNIVERSITY OF ULM (GERMANY);RAGHAVACHAR A, DEPARTMENT OF CLINICAL PHYSIOLOGY AND OCCUPATIONAL MEDICINE, UNIVERSITY OF ULM (GERMANY);CALVO W, DEPARTMENT OF CLINICAL PHYSIOLOGY AND OCCUPATIONAL MEDICINE, UNIVERSITY OF ULM (GERMANY);CARBONELL F, DEPARTMENT OF CLINICAL PHYSIOLOGY AND OCCUPATIONAL MEDICINE, UNIVERSITY OF ULM (GERMANY);FLIEDNER T M DEPARTMENT OF CLINICAL PHYSIOLOGY AND OCCUPATIONAL MEDICINE, UNIVERSITY OF ULM (GERMANY), DEPARTMENT OF CLINICAL PHYSIOLOGY AND OCCUPATIONAL MEDICINE, UNIVERSITY OF ULM (GERMANY)
Bibliographic Reference: RECENT ADVANCES IN BONE MARROW TRANSPLANTATION, 1983, PP. 857-863 PUBLISHED BY ALAN R. LISS INC., 150 FIFTH AVENUE, NEW YORK, NY 10011 (USA)
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