METABOLIC BEHAVIOUR OF INORGANIC FORMS OF ANTIMONY IN THE RAT
Different aspects of the metabolism of Sb in rats have been investigated by neutron activation analysis (NAA) and radiotracer methods. An obvious accumulation of Sb was observed in the blood of untreated rats as a function of age probably due to interactions with red blood cell (RBC) components. Differences were found in the metabolic pathways of low doses of Sb-3+ and Sb-5+ species. While Sb-3+ ions which become strongly bound to the RBC are excreted mainly via faeces the Sb-V ions are essentially present in a dialyzable form in the plasma with a higher level of excretion mainly via urine. Other mechanisms such as via the biliary system and a direct transfer into the gut are also involved in the elimination of Sb.
Bibliographic Reference: INTERNATIONAL CONFERENCE ON HEAVY METALS IN THE ENVIRONMENT, HEIDELBERG (GERMANY), SEPT. 6-9, 1983 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31159 ORA
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Record Number: 1989122026000 / Last updated on: 1987-01-01
Available languages: en