MOLECULAR SPECTRA AND MUTAGENIC ACTIVITY OF SOME NITROGEN CONTAINING HETEROCYCLIC AROMATIC COMPOUNDS
The molecular spectra of a number of polycyclic aromatic compounds which are frequently observed in fossil fuel combustion and conversion processes were determined with special emphasis on N-heterocycles (benz- and dibenzacridines) and some amino derivatives. At the same time the compounds were screened for mutagenic activity (Ames test). The Ames tests were carried out using two different bacterial strains (Salmonella typh. TA98 and TA100) in the presence and absence of metabolic activation (S-9 mixture). The purity of the compounds tested was in most cases better than 99.5 %. The UV- and fluorescence spectra of the benz- and dibenzacridine isomers are presented and discussed. With the exception of 10-azabenzo(a)pyrene, all compounds tested showed no mutagenic activity in absence of metabolic activation. In presence of S-9 in the dibenzacridine series, appreciable mutagenic activities were found for all five isomers tested, especially in TA 100. Very high mutagenic activities (more than 10.000 revertants per plate or 2.000 rev./mug in one case) were found in these screening tests for three isomers of aminobenzo(c)phenanthrene and 3-aminofluoranthene. For some unsubstituted PAH compounds for which no mutagenicity data were previously available significant effects in strain TA 100 were found for benzo(c)chrysene, benzo(a)fluoranthene and dibenzo(a,1)-pyrene, whereas benzo(b)chrysene showed negligible activity.
Bibliographic Reference: 8TH INTERNATIONAL SYMPOSIUM ON POLYNUCLEAR AROMATIC HYDROCARBONS, COLUMBUS, OHIO (USA), OCT. 26-28, 1983 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31245 ORA
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Record Number: 1989122035800 / Last updated on: 1987-01-01
Available languages: en