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Abstract

In general, the expression of IgD on the surface of B-lymphocytes has become associated with distinct stages of B-cell development. Hence mu**+ delta**- populations are well recognized as a feature of the earliest stages of B- cell differentiation**1-4 as well as comprising a subset of memory cells appearing after antigenic stimulation. However, the existence of a distinct delta**-B-cell lineage separating from cells which transiently or permanently express delta in differentiation has been supported by relatively little evidence. In this paper we present data which indicate that many of the mature delta**- B-cells found in the spleen of rats have developed without ever expressing delta. The experimental anti-rat-delta**7 in order to eliminate delta expressing B- cells as they appear. It is shown that these rats acquire delta**- B-cells in secondary lymphoid organs which are not obviously different from those delta**- B-cells found in control animals. The range of immunoglobulin isotypes which are produced in these rats has been assessed. This suggests that the profile of antibody synthesized by this delta**- population does not totally overlap that produced by B-cells that have expressed delta during their development.

Additional information

Authors: BAZIN H, UNIVERSITE CATHOLIQUE DE LOUVAIN (BELGIUM);UNIVERSITY OF BIRMINGHAM (UK);GRAY D, UNIVERSITE CATHOLIQUE DE LOUVAIN (BELGIUM);UNIVERSITY OF BIRMINGHAM (UK);MC LENNAN I, UNIVERSITE CATHOLIQUE DE LOUVAIN (BELGIUM);UNIVERSITY OF BIRMINGHAM (UK);PLATTEAU B UNIVERSITE CATHOLIQUE DE LOUVAIN (BELGIUM), UNIVERSITE CATHOLIQUE DE LOUVAIN (BELGIUM);UNIVERSITY OF BIRMINGHAM (UK);UNIVERSITY OF BIRMINGHAM (UK), UNIVERSITE CATHOLIQUE DE LOUVAIN (BELGIUM);UNIVERSITY OF BIRMINGHAM (UK)
Bibliographic Reference: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, (1982), PP. 157-174
Record Number: 1989122036500 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en