PREVENTION OF INTESTINAL UPTAKE OF RADIOACTIVE ALKALINE EARTH BY NEW AGENTS
A boron-aryl-cryptand (BAC), a member of a new class of not yet published agents (BACs), suitable to bind certain radioactive and non-radioactive cationic elements, was tested in rats in order to know if these compounds are able to remove 85-Sr from the intestinal tract. We needed to learn, if the strontium - BAC complex is strong enough to persist during the gastrointestinal passage. The performed 85-Sr-BAC complex as well as 85-Sr-only were given orally in acid resistant capsules to rats. The excretion of the radionuclide was measured during the five following days, by the total body retention (TBR). In order to obtain a comparable effect by alginates under comparable conditions an about 65-fold molar amount of alginates is needed. The extremely insoluble compound did not exert any overtoxic effect. We conclude therefore BACs as being suitable to remove 90-Sr and other alkaline earthes (Ba,Ra) from the intestine. Calcium is not removed by BACs. Further studies are necessary.
Bibliographic Reference: 7TH INTERNATIONAL CONGRESS OF RADIATION RESEARCH, AMSTERDAM (THE NETHERLANDS), JULY 3-8, 1983 - WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31137 ORA
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Record Number: 1989122036700 / Last updated on: 1987-01-01
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