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Abstract

Induction of chromosome aberrations in cultured blood lymphocytes is a sensitive indicator for exposure to radiation and other mutagenic agents. A principal advantage of this test is that the aberrations are preserved for long periods of time allowing to assess damage accumulated over a lengthy period of time. Cytogenetic determinations suffer from the disadvantages that they are time consuming and demand specialized personnel. Whereas the behaviour in man after acute whole body irradiation can be fairly well predicted from such data, information is scanty after partial body and fractionated exposure. Studies in radiotherapy patients can supply these data and, if sequential samples are taken, yield indications on the individual radiosensitivity of the persons involved. The linear component of the dose effect curves corresponded well with the irradiated body volume when aberrations after therapy of mammary cancer were compared with those induced in vitro. The square component appeared smaller, probably as a result of repair intervening between the therapy fractions.

Additional information

Authors: LEONARD A, SCK/CEN MOL (BELGIUM);GERBER G B SCK/CEN MOL (BELGIUM), SCK/CEN MOL (BELGIUM)
Bibliographic Reference: BIOLOGISCHE INDIKATOREN FUER DIE ERMITTLUNG VON STRAHLENEXPOSITIONEN, SCHLOSS REISENSBURG (GERMANY), DEC. 12-16, 1983 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31379 ORA
Availability: Can be ordered online
Record Number: 1989122059800 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en