EFFECTS OF LONG-TERM IRRADIATION ON RAT B LYMPHOCYTES
Different B cell lineages have been distinguished on the basis of their surface expression of IgM, IgD or other Ig markers, their circulating or non-circulating capacities and their localization in lymphoid tissues. Their physiological and functional characteristics are still not perfectly known, but major differences in their capacities to respond to various antigenic stimuli have already been found between them. Likewise, they differ in the isotypes of immunoglobulins that they can synthesize. The effects of long-term irradiation on B lymphocytes have been studied in rats submitted to chronic irradiation (cobalt 60) of 0.07 Gy per day for up to 135 days. Although such a continuous irradiation was able to reduce the production of preleptotene spermatocytes in these rats to 10 % of control by an exposure of only 30 days, in these same rats, no evidence of deleterious change was observed after a time exposure from 9 to 135 days: in the spleen, both the follicular and the marginal zone B cell populations were not significantly different from those of the control group; in the serum, the immunoglobulin concentrations of the IgM, IgD, IgA, IgE, IgG1 IgG2a, IgG2b and IgG2c classes were also not significantly different from those of the non-irradiated animals kept in the same conditions (Figure 1). Hence, a steady equilibrium of the B lymphocyte cell populations can be obtained under a continuous irradiation of 7 cGy per day. Groups of animals given a chronic exposure of ionizing radiations from 12 to 30 cGy per day are presently under study.
Bibliographic Reference: EUROPEAN SOCIETY FOR RADIATION BIOLOGY, 18TH ANNUAL MEETING, ZUERICH (SWITZERLAND), SEPT. 9-13, 1984 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31490 ORA
Availability: Can be ordered online
Record Number: 1989122070900 / Last updated on: 1987-01-01
Available languages: en