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Abstract

The distribution, retention and biotransformation of arsenocholine, an organic arsenic compound present in certain seafood, have been studied in rats, mice and rabbits by use of synthesized 73-As labelled arsenocholine. Orally administered arsenocholine was almost completely absorbed from the gastro-intestinal tract in mice and rats. In all species 70-80 % of the administered dose was excreted in the urine within 3 days [73-As] arsenobetaine was the main urinary metabolite; [73-As] arsenocholine was found in the urine of the first day only. No degradation to inorganic arsenic, mono- or dimethylarsenic acids, or trimethylarsine oxide was observed. In the tissues the 73- As activity retained was found in the form of [73-As] arsenobetaine and [73-As] arsenophospholipids. Tissues with longest retention times were prostate, epididymis, testes, myocardium, liver, adrenal cortex, pancreas, dental pulp and pituitary gland.

Additional information

Authors: MARAFANTE E JRC ISPRA ESTAB. (ITALY) VAHTER M NATIONAL INSTITUTE OF ENVIRONMENTAL MEDICINE AND THE KAROLINSKA INSTITUTE, STOCKHOLM (SWEDEN) DENCKER L UNIVERSITY OF UPPSALA (SWEDEN) , JRC ISPRA ESTAB. (ITALY);NATIONAL INSTITUTE OF ENVIRONMENTAL MEDICINE AND THE KAROLINSKA INSTITUTE, STOCKHOLM (SWEDEN);UNIVERSITY OF UPPSALA (SWEDEN)
Bibliographic Reference: THE SCIENCE OF THE TOTAL ENVIRONMENT, VOL. 34 (1984), PP. 223-240
Record Number: 1989122081500 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en