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Abstract

The application of combined radiation on biological systems may result in the following different biological effects. a) Additive action b) Less than additive action c) More than additive action (synergistic action) d) Less than the action of one component (inhibiting action) These effects may be dependent on quality and/or site of irradiation but also on dose, dose rate and duration of irradiation periods. In our experiments, 4 week old NMRI mice were usually treated with a combination of a short-term high dose rate followed by a longer period of low to very low level of dose rate of incorporated alpha and beta emitters. Osteosarcoma incidences were studied. The aim of these experiments has been to show the possibility of the existence of critical values for doses and dose rates which represent the initializing and promoting agents - according to the multistage theory of carcinogenesis - and whether this is also dependent on radiation quality. Thus the rather high initial dose and dose rate may be considered as an initializing event and the following long-term low level irradiation as a promoting agent.

Additional information

Authors: MUELLER W A GESELLSCHAFT FUR STRAHLEN- UND UMWELTFORSCHUNG MBH MUNCHEN NEUHERBERG (GERMANY), GESELLSCHAFT FUR STRAHLEN- UND UMWELTFORSCHUNG MBH MUNCHEN NEUHERBERG (GERMANY)
Bibliographic Reference: EULEP BONE WORKSHOP, HARWELL (UK) SEPT. 26 1983 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31471 ORA
Availability: Can be ordered online
Record Number: 1989122081600 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en