MODELS OF CELLULAR RADIATION ACTION
A survey is given of fundamental approaches to the interpretation of radiobiological data. Special emphasis is on the conclusions that can be drawn from the linear quadratic dose dependence of cellular radiation effects. Linking the more recent analyses in terms of microdosimetry with earlier biophysical investigations the evolution of the presently relevant studies is traced. A critical assessment is made of the interpretation of cellular radiation effect in terms of the interaction of sublesions and of the alternative interpretation that has been attempted in terms of a dose dependent reduction of repair efficiency. Since the interaction of sublesions can also be understood in terms of misrepair the two interpretations are not entirely exclusive. However, as also pointed out, there is, at present, no substantiated evidence for damage of the repair system at doses of biological interest, nor is there evidence for a repair overload due, for example, to a limited amount of repair enzymes. It is concluded that the interpretation in terms of the interaction of sublesions is still the most likely interpretation of the observed linear - quadratic dose dependences, and it is suggested that the further study of the various repair processes, especially the search for a possible role of long-path repair, is required.
Bibliographic Reference: INTERNATIONAL CONGRESS OF RADIATION RESEARCH, AMSTERDAM (THE NETHERLANDS), JULY 3-8, 1983 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31655 ORA
Availability: Can be ordered online
Record Number: 1989122091800 / Last updated on: 1987-01-01
Available languages: en