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Abstract

Data are presented on the metabolic behaviour of mercuric mercury(Hg**++) in rats and rabbits exposed to three different doses of 203-Hg labelled mercury chloride: 5, 50 and 500 mug Hg/kg b.w.. The pattern of elimination of the metal in the faeces and urine varied with the dose administered. The kidney showed the highest capacity to accumulate and retain mercury, whereas it was significantly and rapidly eliminated from the liver over the experimental time period of 6 days. In the soluble cytoplasmic fraction of liver and kidney, mercury was largely found to be incorporated into metallothionein. In the liver, the amount of metal associated with metallothionein decreased greatly during the 6 days after dosing. In the kidney, a similar decrease was found only in rats administered with the highest dose. The hepatic and renal metallothionins obtained from rats dosed with 1,500 mug Hg/kg b.w. showed a different behaviour when fractionated by ion exchange chromatography and polyacrylamide gel electrophoresis. While the liver metallothionin was resolved in the two typical iso-metallothionins, that isolated from the kidney could not be similarly fractionated.

Additional information

Authors: LORENZON G, JRC ISPRA ESTAB. (ITALY);MARAFANTE E, JRC ISPRA ESTAB. (ITALY);SABBIONI E JRC ISPRA ESTAB. (ITALY), JRC ISPRA ESTAB. (ITALY)
Bibliographic Reference: EUR 9004 EN (1984) MF, 46 P., BFR 120, BLOW-UP COPY BFR 230, EUROFFICE, LUXEMBOURG, POB 1003
Availability: Can be ordered online
Record Number: 1989122102700 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en