IMMUNODEFICIENT ANIMAL MODEL - SUPPRESSION OF B-LYMPHOCYTES BY INJECTIONS OF ANTI-IMMUNOGLOBULIN ANTIBODIES
The technique of mu suppression can give an experimental model of laboratory animals without a B lymphocyte. This technique consists in neonatally initiated, repeated injections of anti-mu heterologous antibodies. Rats as well as mice and probably animals of other species can be obtained without B lymphocytes, plasma cells and serum immunoglobulins. It is also possible to suppress only one immunoglobulin class, in the case of the IgD, IgA, IgE and IgG classes by using the corresponding antiserum. However, the results will never be as clear as those obtained with a mu suppression.
Bibliographic Reference: L'ANIMAL DE LABORATOIRE EN IMMUNOLOGIE ET IMMUNOGENETIQUE, ORLEANS (FRANCE), MAY 16-18, 1984 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER F 31694 ORA
Availability: Can be ordered online
Record Number: 1989123005900 / Last updated on: 1987-01-01
Available languages: fr