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Abstract

In view of their environmental occurrence and the lack of relevant data the induction effect of five heterocyclic aromatic compounds (two sulfur and three nitrogen containing pollutants) on rat liver microsomal chrysene oxidation was investigated and compared to the corresponding effects of two ubiquitous polycyclic aromatic hydrocarbons (benzo-(a)-pyrene and indeno-(1,2,3)-(cd)-pyrene.) The results obtained from incubations with liver microsomes of variously pretreated rats in presence of various inducers indicate a pronounced induction of chrysene metabolism, especially after treatment with the two sulfur heterocycles (benzo(b)naphtho (2,1-d)- and - (1,2-d)thiophene) and indeno (1-2,3-cd)pyrene. Thus, these three ubiquitous environmental pollutants must be considered as potent cocarcinogens.

Additional information

Authors: KARCHER W, JRC PETTEN ESTAB. (THE NETHERLANDS);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY);JACOB J, JRC PETTEN ESTAB. (THE NETHERLANDS);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY);GRIMMER G, JRC PETTEN ESTAB. (THE NETHERLANDS);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY);SCHMOLDT A JRC PETTEN ESTAB. (THE NETHERLANDS), JRC PETTEN ESTAB. (THE NETHERLANDS);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY), JRC PETTEN ESTAB. (THE NETHERLANDS);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY), JRC PETTEN ESTAB. (THE NETHERLANDS);BIOCHEMICAL INSTITUTE FOR ENVIRONMENTAL CARCINOGENS, AHRENSBURG (GERMANY);INSTITUTE FOR FORENSIC MEDICINE, UNIVERSITY HAMBURG (GERMANY)
Bibliographic Reference: INTERNATIONAL SYMPOSIUM ON POLYCYCLIC AROMATIC HYDROCARBONS, COLUMBUS/OHIO (USA), OCT. 30-NOV. 1, 1984 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31680
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Record Number: 1989123006000 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en