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Abstract

Studies on various aspects of chromium metabolism in rats were carried out using radiotracer methods and neutron activation analysis. Chromium in the blood administered as 51-Cr (III) is present nearly totally in the plasma mainly bound to transferrin whereas when administered as 51-Cr (VI) more than 80 % enters the red blood cells within 40 minutes and is transformed to a form different from that originally administered. Chromium concentration in the target organs (liver, kidney, lung, spleen and testis) is different due to the valency state and to the route of injection. The elimination of chromium is also dependent on the chemical form and the route of administration. The biliary excretion has been investigated after i.v. injection of 51-Cr (III) and 51-Cr (VI) the former being nearly 50 times lower. Strong differences in the urinary and fecal excretion of 51-Cr (III) and 51-Cr (VI) are seen after i.v. and i.t. injection: after i.v. administration, during the first day, Cr (III) is excreted via urine to 8 % of the dose and via feces only to 0.5 %; after Cr (VI) i.v. injection about 30 % of the dose is excreted in the urine and 2 % in feces.

Additional information

Authors: EDEL J, JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY);SABBIONI E, JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY);PIETRA R, JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY);WALLAEYS B, JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY);MANZO L JRC ISPRA ESTAB. (ITALY), JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM), JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY);UNIVERSITY OF PAVIA (ITALY), JRC ISPRA ESTAB. (ITALY);RIJKSUNIVERSITEIT, GENT (BELGIUM);UNIVERSITY OF PAVIA (ITALY)
Bibliographic Reference: 5TH INTERNATIONAL SYMPOSIUM TRACE ELEMENT METABOLISM IN MAN AND ANIMALS, ABERDEEN (SCOTLAND), JUNE 29-JULY 4, 1984 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31520 ORA
Availability: Can be ordered online
Record Number: 1989123006200 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en