GENETICAL AND BIOCHEMICAL STUDIES OF A DOMINANT CATARACT MUTANT IN MICE
A spontaneous mutation causing a nuclear opacity of the lens of the eye was detected among (101xC3H)F-1 hybrid mice. The nuclear opacity, provisional gene symbol Nop, is inherited as a single autosomal dominant gene. Penetrance on the genetic background of the 101 strain is complete. Heterozygotes and homozygotes are viable and fertile. The amount of protein after centrifugation at 3000 g is reduced in the cataractous lens. After isoelectric focusing a band at pH 8.5 in the protein pattern is missing. The glutathione redox state of the cataractous lens is also affected. The amount of oxidized glutathione relative to the total amount of glutathione is increased from 2.7 to 7.8 % in the Nop/+ mutant (P < 0.05). However, the concentration of ATP in the cataractous lens is unchanged.
Bibliographic Reference: EXP. EYE RES., VOL. 39 (1984), PP. 37-45
Record Number: 1989123029500 / Last updated on: 1987-01-01
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