LUNG MODELLING FOR INHALATION OF RADIOACTIVE MATERIALS. PROCEEDINGS OF A MEETING JOINTLY ORGANIZED BY THE COMMISSION OF THE EUROPEAN COMMUNITIES AND THE NATIONAL RADIOLOGICAL PROTECTION BOARD
Inhalation is an important route of entry of radioactive materials in the body. For the purpose of radiation protection, one must be able to assess the exposure to lung and extrapulmonary tissues after such exposure. The radiation protection programme of the Commission of the European Communities, therefore, emphasizes studies into models which allow the estimate of the spatial and temporal distribution of doses in the respiratory system and the transfer to other tissues. On the basis of such models, limits of intake can be set and the risks from inhalation of radioactive materials may be assessed. Moreover, such models are often also useful for evaluating the fate of other inhaled toxic agents. New experimental results and theoretical considerations suggest that present lung models needed to be improved. Therefore, a workshop on Lung modelling for inhalation of radioactive materials was jointly organized by the Commission of the European Communities and the National Radiological Protection Board (NRPB) at Oxford, 26-28 March 1984. The present proceedings of this workshop review the physiological and anatomical basis for lung models. Several papers deal with studies on deposition and clearance of radioactive particles in the lungs of man and experimental animals. Absorption of radioactive gases is another topic of the workshop. Following the discussion of the mechanism by which radioactive and other particles are cleared from the lungs, the relation between particles deposited and target cells is considered. Various lung models for dosimetric purposes are presented next, and the workshop closed with a round table discussion on the needs for future studies and the problems involved in developing improved lung models.
Bibliographic Reference: EUR 9384 EN (1984) FS, 340 P., BFR 1200, EUROFFICE, LUXEMBOURG, POB 1003
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Record Number: 1989123029600 / Last updated on: 1987-01-01
Available languages: en