COMPARISON OF THE INDUCTION OF PULMONARY NEOPLASMS IN SPRAGUE-DAWLEY RATS BY FISSION NEUTRONS AND RADON DAUGHTERS
Pulmonary carcinomas were recorded in a life span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon daughter inhalations in the same strain of rats. A simultaneous maximum likelihood analysis is applied jointly to all experimental groups from the radon inhalation and the fission neutron study. The dependence of the resulting coefficients for the different groups on absorbed dose or inhalation dose permits a derivation of equivalence ratios. At low doses the equivalence ratio is 3 WLM (working level months) of radon daughter exposure to 1 mGy of fission neutrons. At higher doses the equivalence ratio decreases. The neutron data are also utilized to derive mortality corrected lifetime incidences of pulmonary carcinomas in the exposed animals. At low doses the relation is consistent with linearity, but sublinearity (dose exponent < 1) cannot be excluded.
Bibliographic Reference: RADIATION RESEARCH, VOL. 98 (1984), NO. 3,PP. 519-535
Record Number: 1989123030000 / Last updated on: 1987-01-01
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