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Abstract

The effects of induced mutations are generally detrimental, therefore, it is important to identify potential mutagens and to assess their possible impact on future generations. One possible way to identify hazards and risks is to consider the problem as a sequence of steps. The first step is the Hazard Identification, the determination of whether a substance is mutagenic. The second step is the Hazard Evaluation, the investigation of the chemical, physical, and biological factors that affect mutagenesis. The third step is the Risk Estimation, the estimation of effect per unit of exposure. the risk estimation can be divided into two components: estimation of mutagenic effects on germ cells (damage) and estimation of effects on health and welfare of future generations (impact). There are two main approaches in making genetic risk estimates. One of these, termed the direct method, expresses risks in terms of expected frequencies of genetic changes induced per unit dose. The other, referred to as the doubling dose method or the indirect method, expresses risks in relation to the observed incidence of genetic disorders now present in relation to the observed incidence of genetic disorders now present in man. The estimated numbers are poor indicators of severities among the various individuals affected by the hereditary conditions. These aspects will be discussed in detail.

Additional information

Authors: EHLING U H INSTITUT FUER GENETIK, GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG MBH MUENCHEN, NEUHERBERG (GERMANY), INSTITUT FUER GENETIK, GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG MBH MUENCHEN, NEUHERBERG (GERMANY)
Bibliographic Reference: TENTH ANNUAL CONFERENCE OF THE ENVIRONMENTAL MUTAGEN SOCIETY OF INDIA, BOMBAY (INDIA) FEB. 18-21, 1985 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31929 ORA
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