HUMAN EXPOSURE TO TRACE ELEMENTS - ALUMINIUM CONTAINING PHOSPHATE BINDERS AS POTENTIAL SOURCE OF TRACE METALS IN THE TREATMENT OF UREMIC PATIENTS
Neutron activation analysis has been used to determine at least 37 elements in aluminium containing phosphate binders, e.g., Maalox and Alucol tablets and Maalox suspension, used in the treatment of uremic patients. Among the phosphate binders analyzed, Maalox suspension exposes the patients to the lowest level of trace elements. Although the phosphate binders analyzed can be considered products with high chemical purity as regards their trace element composition, some elements ingested in association with drugs, such as barium (Ba), gallium (Ga), lanthanum (La), scandium (Sc), strontium (Sr), thallium (Th), uranium (U), and tungsten (W), have been detected in amounts that may significantly increase their normal level due to diet. Further research is needed to assess the potential harmful effects of these elements in uremic patients undergoing treatment with aluminium phosphate binders.
Bibliographic Reference: TRACE ELEMENTS IN MEDICINE, VOL. 1 (1984), NO. 2, PP. 71-75
Record Number: 1989123042300 / Last updated on: 1987-01-01
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