Community Research and Development Information Service - CORDIS

Abstract

Neutron activation analysis has been used to determine at least 37 elements in aluminium containing phosphate binders, e.g., Maalox and Alucol tablets and Maalox suspension, used in the treatment of uremic patients. Among the phosphate binders analyzed, Maalox suspension exposes the patients to the lowest level of trace elements. Although the phosphate binders analyzed can be considered products with high chemical purity as regards their trace element composition, some elements ingested in association with drugs, such as barium (Ba), gallium (Ga), lanthanum (La), scandium (Sc), strontium (Sr), thallium (Th), uranium (U), and tungsten (W), have been detected in amounts that may significantly increase their normal level due to diet. Further research is needed to assess the potential harmful effects of these elements in uremic patients undergoing treatment with aluminium phosphate binders.

Additional information

Authors: PIETRA R, JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG;SABBIONI E, JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG;MOUSTY F, JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG;BRANCACCIO D, JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG;BERLIN A JRC ISPRA ESTAB. (ITALY), JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG;S. PAOLO HOSPITAL, MILAN (ITALY), JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG;CEC LUXEMBOURG, JRC ISPRA ESTAB. (ITALY);S. PAOLO HOSPITAL, MILAN (ITALY);CEC LUXEMBOURG
Bibliographic Reference: TRACE ELEMENTS IN MEDICINE, VOL. 1 (1984), NO. 2, PP. 71-75
Record Number: 1989123042300 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en