ACTIVATION OF ENDOGENOUS C-TYPE RETROVIRAL GENOMES BY INTERNAL ALPHA IRRADIATION OF MICE WITH 224-RADIUM
Sensitive co-cultivation techniques were applied to study the radiation induced activation of endogenous retroviral genomes in different mouse strains by the alpha-emitting radionuclide 224-Radium. Activated infectious C-type retrovirus were detected in spleen, bone marrow and bone tissues of C57BL/6-, BALB/c- and NMRI mice. The titres of high dose irradiated animals were higher than those found in low dose irradiated animals. Infectious retrovirus could be detected with a dose of 13.2 rad (maximum dose rate 0.9 rad/day) in the skeleton, and a dose of 4.2. rad (maximum dose rate 0.3 rad/day) in the spleen. The virus activation pattern was different in the three mouse strains. These data indicate that activation of endogenous retroviral genomes by alpha irradiation shows a dose effect relationship and a dependence on the genetic background of the mouse.
Bibliographic Reference: RADIATION AND ENVIRONMENTAL BIOPHYSICS, VOL. 24 (1985), PP. 17-25
Record Number: 1989123042600 / Last updated on: 1987-01-01
Available languages: en