INTESTINAL ABSORPTION AND EXCRETION OF 201-THALLIUM (201-TL) IN THE RAT
The gastrointestinal transport of 201-Tl labelled monovalent thallium has been studied in normal and rats with cannulated bile ducts using an in vivo ligated loop technique. A marked difference in the TI absorptive capacity among the various sections of the gut was observed. 201-Tl was taken up more quickly from the colon than from any other segment and the uptake from the ileum and jejunum was higher than from the stomach. In addition, considerable amounts of the intravenously administered thallium were excreted into the intestinal lumen.The biliary excretion was very low compared with the direct transfer of 201-Tl across the gastrointestinal wall that occurred against a tissue to plasma concentration gradient. In the rat, the large intestine seems to be the major area for the enteral re-absorption and recycling of thallium (I) ions.
Bibliographic Reference: XXIVTH CONGRESS OF THE EUROPEAN SOCIETY OF TOXICOLOGY, ROMA (ITALY), MARCH 28-30, 1983 AND ARCH. TOXICOL. SUPPL. 7 (1984), PP. 446-450 WRITE TO CEC LUXEMBOURG DG XIII/A2, POB 1907, MENTIONING PAPER E 30961 ORA.
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Record Number: 1989123042900 / Last updated on: 1987-01-01
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