RISK AND EFFECT OF RADIUM-224 THERAPY IN CASES OF ANKYLOSING SPONDYLITIS
1426 patients with Bechterew's disease, who had formerly (up to 30 years ago) been treated with 224-Ra were included in an epidemiological study. Among the 363 mortalities recorded, 3 were due to tumours in the skeletal region, of these 2 were observed in the haemopoietic system. On the other hand: in a group of patients, treated with higher doses, studied by Spiess, only 1 out of 55 tumours was of the haemopoietic system; a high incidence of such tumours was found among Hiroshima victims. In an effort carefully to reconsider the drug 224-Ra, two study groups of 200 patients in all were investigated 5-20 years after an injection therapy for clinical and radiological symptoms. The results: main benefit of the drug: its analgesic efficacy; apparently no decisive influence on the course of the disease; no radiation induced malignomas or other radiation damage was detected. In comparison with chemical agents used in the treatment of a.sp.: 224-Ra is very useful in cases of absolute indication.
Bibliographic Reference: THERAPIEWOCHE, VOL. 33 (1983), PP. 3753-3755
Record Number: 1989123081100 / Last updated on: 1987-01-01
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