METABOLISM IN THE RAT OF CADMIUM BIOCOMPLEXES FROM EDIBLE MUSSELS EXPOSED TO 109-CDCL-2
The metabolism in the rat of 10C-d biocomplexes present in the tissues of the edible mussel Mytilus galloprovincialis, previously exposed to 109-CdCl-2, was studied. The tissue distribution and binding of 109-Cd were compared to those caused by an equal dose of 109-Cd as CdCl-2 or rat liver Cd- metallothionein. Administration of mussel 109-Cd to rats resulted in an initial accumulation of 109-Cd in the kidneys due to the presence of 109-Cd metallothionein, which constituted 25% of the**109Cd in the tissues of the mussels. Other 109-Cd biocomplexes present in the mussel tissues were metabolized in the rat in a way similar to that of inorganic cadmium, i.e. initial accumulation in the liver. These findings indicate that the ingestion of seafood rich in metallothionein may give rise to a faster increase of renal cadmium levels than the consumption of a similar amount of inorganic cadmium.
Bibliographic Reference: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, VOL. 9 (1985), PP. 209-215
Record Number: 1989123081200 / Last updated on: 1987-01-01
Available languages: en