INCORPORATION EXPERIMENTS WITH COMBINED APPLICATION OF DIFFERENT BONESEEKERS
The aim of these experiments is to show the possibility of the existence of critical values for doses and dose rates which represent the initiating and promoting agents for induction of bone tumours and whether those effects are also dependent on radiation quality. This question was also dealt with in extensive protraction incorporation experiments using short-lived radionuclides. The application of combined radiation on biological systems may results in the following different biological effects: a) Additive action b) Less than additive action c) More than additive action (synergistic action) d) Less than the action of one component (inhibiting action), and these effects may be dependent on quality and/or site of irradiation but also on dose, dose rate and duration of irradiation periods. Our experiments showed that combined incorporation of different boneseekers can result in additive and more than additive effect concerning the incidence of bone tumours, provided that the initial dose rate was not too high. According to the multistage theory of carcinogenesis the short-term initial dose and dose rate may be considered as an initiating event and the following long term low level irradiation as a promoting agent.
Bibliographic Reference: RADIATION AND ENVIRONMENTAL BIOPHYSICS, VOL. 23 (1984) PP. 113-115
Record Number: 1989123081300 / Last updated on: 1987-01-01
Available languages: en