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Abstract

Environmental biochemical toxicology research on trace elements requires the use of sensitive and sophisticated analytical techniques to determine mug/kg concentrations of trace metals in tissues and intracellular components of laboratory animals and humans. The results provided by these techniques are needed for an understanding of the biochemical mechanisms and the biotransformations involving trace metals. Nuclear and radioanalytical methods were developed and are currently applied to metallobiochemical research at the JRC Ispra. Typical applications of these techniques to the study of the metabolism of inorganic arsenic in rats and rabbits show different levels of arsenic in the tissues of the two species. These levels are established by different degrees of interaction of the element with the intracellular components of the two species. These interactions are responsible for the detoxification of arsenic. Detoxification is closely related to the rate of methylation of arsenic in the tissues.

Additional information

Authors: SABBIONI E, JRC ISPRA ESTAB. (ITALY);PIETRA R, JRC ISPRA ESTAB. (ITALY);MOUSTY F, JRC ISPRA ESTAB. (ITALY);CASTIGLIONI M JRC ISPRA ESTAB. (ITALY), JRC ISPRA ESTAB. (ITALY)
Bibliographic Reference: WORKSHOP ON ENVIRONMENTAL INORGANIC CHEMISTRY, S. MINIATO, PISA (ITALY), JUNE 6-11, 1983 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 31074 ORA
Availability: Can be ordered online
Record Number: 1989123087000 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en