Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Kurzbeschreibung

The structural proteins of the lens, the crystallins, can be classified into 5 classes, which are different with respect to the molecular weight, the isoelectric point and the immunological properties. Some of them show special features with respect to the known DNA sequences: 1. The alpha A-2 crystallin of rat, mouse and calf possesses a long non-coding regions at the 3'-end; 2. Rat, mouse and hamster possess a changed splicing pattern, which leads to an additional translation of an intron; 3. Beta- and gamma crystallins possess high internal homologies. The protein domains are separated by introns; 4. The genes for beta and gamma crystallins are assumed to have had common precursors during evolution. The loss of crystallins might have consequences for the transparence of the lens and might lead to lens opacities (cataracts).

Zusätzliche Angaben

Autoren: GRAW J GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, MUENCHEN-NEUHERBERG (GERMANY), GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, MUENCHEN-NEUHERBERG (GERMANY)
Bibliografische Referenz: BIOLOGIE IN UNSERER ZEIT, VOL. 15 (1985), NO. 2, PP. 33-41
Datensatznummer: 1989124018100 / Zuletzt geändert am: 1987-01-01
Kategorie: publication
Verfügbare Sprachen: de