RELATION BETWEEN ENZYMATIC ACTIVITIES AND THE DEGREE OF MALIGNANCY OF HUMAN LYMPHOMAS
The relationship between the intracellular levels of DNA polymerase alpha (DP-alpha), adenosine deaminase (ADA) and lactate dehydrogenase (LDH) and the degree of malignancy of human lymphomas was investigated in 12 non- neoplastic lymph nodes and 88 malignant lymphomas. For non-Hodgkins lymphomas (NHL) the grade of malignancy was established after the Rappaport, Kiel and Working Formulation for Clinical Usage classifications. Non- neoplastic lymph nodes had significantly lower levels of the three enzymes than high-grade malignant NHL. Among NHL, whatever classification was used, the low grade malignant lymphomas had significantly lower levels that the high-grade ones for all the three enzymes. Lymphoblastic and Burkitt's lymphomas were the groups with the highest levels of the three enzymes. Among low grade lymphomas very low values were found in the histological entities defined as DLWD (Rappaport), CLL and lymphoplasmacytoid immunocytoma (Kiel), and group A (WF). Their enzyme levels were always significantly different from other low grade histotypes, and from the intermediate grade ones of the WF. In the Kiel classification polymorphous lymphoplasmacytoid lymphoma, recently recognized as aggressive was characterized by high levels of all three enzymes. These and more findings suggest that intracellular enzyme values may have a role in better defining the prognosis of NHL.
Bibliographic Reference: EUROPEAN JOURNAL OF CANCER AND CLINICAL ONCOLOGY, VOL. 21 (1985), NO. 8, PP. 945-950
Record Number: 1989124019200 / Last updated on: 1987-01-01
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