RELATIONSHIPS BETWEEN CHROMOSOME DAMAGE, CELL CYCLE DELAY AND CELL KILLING INDUCED BY BLEOMYCIN OR X-RAYS
The extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony forming ability. Bleomycin induced much less G-2 delay and chromosome damage than X-rays. We conclude that (1) the major mechanism of cell killing by bleomycin does not involve chromosome damage but the cells pass through a number of division cycles before dying and (2) a common DNA lesion is involved in G-2 delay and chromosome damage.
Bibliographic Reference: MUTATION RESEARCH, VOL. 151 (1985), PP. 83-88
Record Number: 1989124019400 / Last updated on: 1987-01-01
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